Hongming Zhang is a research assistant professor in the Department of Endodontology at the Kornberg School of Dentistry. Prior to coming to Temple, he was a postdoctoral fellow at Virginia Commonwealth University, where he conducted studies on cell-signaling molecules in cancer cells, and later, investigated gene products of a bacterial virus that infects cells of the Lyme disease-causing spirochete, Borrelia burgdorferi. Prior to this, he was a postdoctoral fellow of the Feinberg Graduate School at the Weizmann Institute in Rehovot, Israel. There, using gene cloning and other molecular biological techniques, he investigated the interactions of the tomato and its pathogens Fusarium and Verticillium, and developed transgenic, disease-resistant tomatoes. His current research activity is focused upon genetically engineering bacterial viruses, and lytic enzymes produced by these viruses, to yield new antimicrobial agents that will be therapeutically useful for treating antibiotic-resistant bacterial infections.

Dr. Zhang received a master’s in plant sciences and a PhD in biochemistry and molecular biology from the China Agricultural University in Beijing.

Research Interests

  • Oral Infectious Diseases

Selected Publications

  • Zhang, H., Buttaro, B.A., Fouts, D.E., Sanjari, S., Evans, B.S., & Stevens, R.H. (2019). Bacteriophage ¿Ef11 ORF28 endolysin, a multifunctional lytic enzyme with properties distinct from all other identified Enterococcus faecalis phage endolysins. Applied and Environmental Microbiology, 85(13), pp. 1-22. doi: 10.1128/AEM00555-19
  • Stevens, R.H., Zhang, H., Sedgley, C., Bergman, A., & Manda, A.R. (2019). The prevalence and impact of lysogeny among oral isolates of Enterococcus faecalis. Journal of Oral Microbiology, 11(1). doi: 10.1080/20002297.2019.1643207
  • Tinoco, J.M., Liss, N., Zhang, H., Nissan, R., Gordon, W., Tinoco, E., Sassone, L., & Stevens, R. (2017). Antibacterial effect of genetically-engineered bacteriophage ¿Ef11/¿FL1C(¿36)PnisA on dentin infected with antibiotic-resistant Enterococcus faecalis. Archives of Oral Biology, 82, pp. 166-170. doi: 10.1016/j.archoralbio.2017.06.005
  • Zeng, Q., Nguyen, S., Zhang, H., Chebrolu, H.P., Alzebdeh, D., Badi, M.A., Kim, J.R., Ling, J., & Yang, M. (2016). Release of Growth Factors into Root Canal by Irrigations in Regenerative Endodontics. Journal of Endodontics, 42(12), pp. 1760-1766. doi: 10.1016/j.joen.2016.04.029
  • Zhang, H., Stevens, R.H., & Buttaro, B. (2016). The Muramoyl Amidase Endolysin of Enterococcus faecalis Bacteriophage phiEf11. The Rockefeller University, New York, NY.
  • Tinoco, J.M., Buttaro, B., Zhang, H., Liss, N., Sassone, L., & Stevens, R. (2016). Effect of a genetically engineered bacteriophage on Enterococcus faecalis biofilms. Archives of Oral Biology, 71, pp. 80-86. doi: 10.1016/j.archoralbio.2016.07.001
  • Stevens, R.H., Zhang, H., Hsiao, C., Kachlany, S., Tinoco, E.M.B., DePew, J., & Fouts, D.E. (2016). Structural proteins of Enterococcus faecalis bacteriophage fEf11. Bacteriophage, 6(4), pp. e1251381-e1251381. Informa UK Limited. doi: 10.1080/21597081.2016.1251381
  • Zhang, H., Stevens, R.H., & Buttaro, B. (2016). The Enterococcus faecalis phage PhiEf11 Amidase Endolysin. Paris, France.
  • Yang, M., Zhang, H., & Gangolli, R. (2014). Advances of mesenchymal stem cells derived from Bone marrow and dental tissue in craniofacial tissue engineering. Current Stem Cell Research and Therapy, 9(3), pp. 150-161. doi: 10.2174/1574888X09666140213142258
  • Zhang, H. (2014). Oral Disease and Diabetes Mellitus: Local Health Links Systemic Health. Austin Journal of Endocrinology and Diabetes, 1(3). United States.