Research interest include: Dental Biomaterials Evaluation; Surface Modification of Enamel/Dentin; Remineralization/Caries Treatment; Oral Health Clinical Research; Tissue Engineering/Peptide Drug Delivery; and laboratory/clinical evaluation of Bioactive, "Smart" Materials.

Oral Biomaterials Research Laboratory

Director

Steven Jefferies, DDS, PhD
Professor, Department of Restorative Dentistry
e-mail: steven.jefferies@temple.edu

Facilities

Building 601, Rooms 2L14 and 2L18  (1,000 square feet)

The Department of Restorative Dentistry at the Kornberg School of Dentistry at Temple University maintains a dedicated 1,000 square foot biomaterials testing laboratory under the direction of Dr. Steven R. Jefferies. The laboratory maintains instrumentation for mechanical strength testing of materials and various tissues (Instron); a microhardness/surface modulus analyzer (CSM Instruments); a contact prolifometer (Surftester SE 1700) ; a VC-50 precision diamond saw (Leco); a Model 900 Grinder/Polisher (Southbay Technologies); and several standard light and stereoptical microscopes for taking digital images of the teeth (SLR digital camera/microscope (Olympus DPII Digital Camera/Microscope with Optiva Zoom 100 lens attachment) and a Nikon microscope with digital camera attachment as part of the CSM microhardness tester.

Research Focus

Research interest include: Dental Biomaterials Evaluation; Surface Modification of Enamel/Dentin; Remineralization/Caries Treatment; Oral Health Clinical Research; Tissue Engineering/Peptide Drug Delivery; and laboratory/clinical evaluation of Bioactive, "Smart" Materials. Future research directions include: three-dimensional, micro-CT analysis of early carious lesions and various treatment modalities; therapeutic delivery of osteogenic peptides on calcium and titanium biomaterials; clinical evaluation of new dental biomaterials and therapeutic agents for erosion/demineralization; in-vitro/in-vivo evaluation of bioactive/"smart" biomaterials with respect to "bio-  toughening" properties; and the effect of various oral therapeutics/surface treatments on surface microhardness and material micro surface roughness.

Representative Publications

Jefferies SR, Pameijer CH, Appleby D, Boston D, Galbraith C, Lööf J and Glantz P-O. Prospective Observation of a New Bioactive Luting Cement: 2-Year Follow-Up. Accepted for Publication, Journal of Prosthodontics, March 9, 2011.

Jefferies SR, Boston DW. Conventional polishing techniques versus a nanofilled surface sealer: Preliminary findings regarding surface roughness changes and analysis. J Clin Dent. 2010; 21(1):20-3.

Boston D, Jefferies S. Effects of a 36% Tooth Bleaching Gel on Zinc Phosphate Cement. J Biomed Mater Res B Appl Biomater. 2010 Feb;92(2):456-61

Jefferies SR, Pameijer CH, Appleby D, Boston D, Lööf J and Glantz P-O. One year clinical performance and post-  operative sensitivity of a bioactive dental luting cement – A prospective clinical study;Swed Dent J 2009;33(4):193-9.

Jefferies SR, Pameijer CH, Lööf J, Appleby D, and Boston D. Clinical Performance with a Bioactive Dental Luting Cement- A Prospective Clinical Pilot Study; J Clin Dent. 2009;20(7):231-7.

Jefferies SR, Boston DW, Dambrow MP, and Galbraith CT. Comparison of detachment forces of two implant overdenture attachment types: Effect of detachment speed. American Journal of Dentistry 2008 Aug; 21(4):244-50.

Boston DW, Jefferies SR, and Gaughan JP. The relative location of the dye staining endpoint indicated propylene glycol-  based caries dye versus conventional propylene glycol-  based caries dye. European Journal of Dentistry. Vol. 2, January 2008: 29 – 36.

Jefferies S, Moore K, Hansen V, Smith D, Boston D, Whitaker E, and Speronello B. Pilot In-Vitro Evaluation of a Novel Tooth Whitenng Agent; Abstract 82, Oral Presentation: Session 20, Key Address and Back to the Future, AADR Annual Meeting, March 4, 2010, Washington.DC Boston

D, Jefferies S. Effect of Bleaching on Microhardness and Modulus of Flowable Composite (IADR/AADR/CADR 87th General Session and Exhibition (April 1-4, 2009) J Dent Res 88 (Special Issue A): Abstract No. 3274, 2009 (www.dentalresearch.org)

Jefferies S, Pameijer CH, Lööf J, Appleby D, Boston D. One Month and Six-Month Clinical Performance of XeraCem™ (IADR/AADR/CADR 87th General Session and Exhibition (April 1-4, 2009) J Dent Res 88 (Special Issue A): Abstract No. 3146, 2009 (www.dentalresearch.org)

Jefferies S, Lööf J, Pameijer CH, Boston D, Galbraith C, and Heransson L. Physical Properties of XeraCem™. IADR/CADR 86th General Session (July 3-5, 2008), J Dent Res 87 (Special Iss B): abstract number 3100, 2008 (www.dentalresearch.org)

Pameijer CH, Jefferies S, Lööf J, and Heransson L Microleakage Evaluation of XeraCem™ in Cemented Crowns IADR/CADR 86th General Session (July 3-5, 2008), J Dent Res 87 (Special Iss B): abstract number 3098, 2008 (www.dentalresearch.org)

Pameijer CH, Jefferies S, Lööf J, and Heransson L. A comparative crown retention tests using XeraCem™, IADR/CADR 86th General Session (July 3-5, 2008), J Dent Res 87 (Special Iss B): abstract number 3099, 2008 (www.dentalresearch.org)

Pameijer CH, Tena E, Jefferies S, Lööf J, Wiksell E, and Heransson L In vitro and in vivo biocompatibility tests of XeraCem™, IADR/CADR 86th General Session (July 3-5, 2008), J Dent Res 87 (Special Iss B): abstract number 3097, 2008 (www.dentalresearch.org)

Jefferies S, Amanda M, Moore K, Podray S, Boston D, and Whitaker E. Development & evaluation of an in-vitro whitening model. AADR 37th Annual Meeting (April 3-5, 2008), J Dent Res 87 (Special Iss A): abstract number 0918, 2008 (www.dentalresearch.org)

Jefferies S., and Boston DW. Surface Roughness Changes Resulting from Nanofilled Surface Sealer. IADR/AADR/CADR Meeting & Exhibition (March 21-24, 2007) Poster Session – Abstract 0952, Seq#112 – Special Topics, March 22, 2007; JDR, Vol. 86, Special Issue A.

Boston, DW. and Jefferies S. DIAGNOdent versus DIAGNOdent Pen for Secondary Caries Recognition. IADR/AADR/CADR Meeting & Exhibition (March 21-24, 2007) Poster Session – Abstract 1646, Seq#189 – Caries, saliva, bleaching, March 23, 2007; JDR, Vol. 86, Special Issue A.