- From the Pennsylvania Turnpike (coming from the west): Exit at Valley Forge interchange and continue east on I-76 to Roosevelt Boulevard extension (Route 1 North). Exit at Broad Street and turn right. The School is one mile south on Broad Street.
- From the Pennsylvania Turnpike (coming from the east): Exit at Route 1 South, or Route 611 South, or Route 309 South. All three routes cross Broad Street . Continue south on Broad Street to Allegheny Avenue . The School is located on the corner of Broad Street and Allegheny Avenue.
- From I-95 (coming from the north or south): Follow the signs to Central Philadelphia and exit at Callowhill Street . Follow straight ahead on Callowhill to Broad Street . Turn right on Broad Street . Travel approximately 3 miles, past Main Campus, to the Health Sciences Campus. The School is located on the right hand side at the corner of Broad Street and Allegheny Avenue.
- From Center City: The northbound C bus from Center City stops at the School of Dentistry at Broad and Allegheny. The northbound local Broad Street Subway from Center City stops at Allegheny Avenue . Intercity trains (Amtrak) stop at 30th Street train station. From there, take the Market-Frankford (Blue Line) to City Hall and transfer to the Broad Street subway.
Public transportation is available and conveniently located to the dental clinics.
Parking is available within walking distance from the School of Dentistry at the Temple University Hospital parking lot on Ontario Street . There is a fee for parking in that lot.